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If you want to lose weight -- and keep it off -- taking fat loss pills is not an effective approach. That said, if you’re looking for a small boost to help your body burn fat, there are a few ingredients that might help. In particular, caffeine, Coleus Forskholii, and Yohimbine might assist with how your body burns fat. But, don’t expect those ingredients to transform your body.

The fat loss industry is a case study in twisted science. Billions of dollars are spent every year on products that promise to help you lose weight by stretching reality. It’s essential for you to know that there is no magic pill, and no fat loss product (as it stands right now) will effectively remove fat from your body without making changes to your diet or exercise behaviors.

But that’s not the end of the story. While you can’t rely on fat loss pills to change your body, there are a few ingredients that can provide a little bit of support to help your body be in a better position to burn fat.

Before you keep reading, remember that “fat loss pills” will not make you thin or burn a lot of calories. But they will provide a little assistance if you’re putting in the work to change your body. View it like shaving cream. Putting that on your body won’t make your hair disappear, but it will make it easier (and possibly more effective) to shave.

The ingredients below (AKA “fat loss pills) might amplify what you are doing if you’re exercising and dieting. After reviewing hundreds of studies, here are the three ingredients that show the most promise.


Caffeine is a powerful natural stimulant and one of the primary ingredients in Ladder Energy. And for a good reason: caffeine can help with focus, attention, memory, and exercise performance. It also causes adrenaline and dopamine to be released, which improves your mood, induces euphoria, and increases excitability.

From a fat loss perspective, caffeine is one of the few products that can help make a small difference. That's because caffeine can produce heat in your body (known as a thermogenic effect), which has a "lipolytic effect." Translation: caffeine causes triglycerides to release fatty acids, which can then be used to fuel your body. When you activate this process, it helps your body burn more fat.

Caffeine supplementation can also inhibit enzymes called phosphodiesterases (PDEs). This puts your body in a better position to lower triglyceride levels in your fat cells, increase heat production in your fat cells, and improve the way your body processes protein. All three of these can play a helpful role in helping your body burn fat and hold on to more lean muscle mass.

Coleus Forskholii

Coleus forskholii is an herbal supplement that doesn’t do too much on its own -- but, when combined with something like caffeine, it can create a better fat-burning environment for your body. The herb can elevate cyclic adenosine monophosphate (cAMP) levels, one of the molecules responsible for the feeling of stimulation from supplements like caffeine. Elevated cAMP levels are associated with lower triglyceride levels in fat cells and increased protein synthesis in muscle cells. Interestingly, research suggests that those who are significantly overweight are more likely to experience the benefits of Coleus forskohlii.


Yohimbine is a compound derived from the bark of the Pausinystalia Yohimbe plant. In theory, Yohimbine makes your fat cells more susceptible to shrinking and has been shown to have promising effects both young and old, as well as people who are both active and inactive. Yohimbine is frequently mixed into fat loss pills because of how it works in your body. In different areas, your body has types of fat cells receptors. Your oblique region -- or where you would experience “love handles” -- has a high number of receptors that respond well to Yohimbine.

However, Yohimbine cannot be used effectively for long periods of time. That’s because excessive yohimbine doses can cause elevated heart rate and anxiety. People with anxiety should be cautious when supplementing yohimbine since even the regular dose can exacerbate pre-existing conditions.

Your Plan

As always, please consult your doctor before taking any supplement or nutritional product. While any of these products could work well individually, it’s essential that you don’t carelessly combine products. The blind mixing of any supplements—and especially those in the fat loss category—is extremely dangerous.

For instance, Yohimbine can be useful, but it must be used carefully, and ideally not with other stimulants like caffeine.

You also have to consider potential interactions with other medications you might be using. Every effective fat loss pill can interact negatively with monoamine oxidase inhibitors (MAOIs), a kind of antidepressant, meaning you should not combine if on those medications.

Your caffeine plan

To supplement caffeine for a prolonged period, take 100 – 200 mg twice a day, for a daily dose range of 200 – 400 mg. People not used to caffeine should start at the low end of the dosage range, such as Ladder Energy, which only uses 100mg per serving. Just rmember: using caffeine in the evening can disrupt your sleep.

Your Coleus Forskohlii Plan

Coleus forskohlii supplementation should not last longer than twelve weeks. More research is needed to determine the long-term effects of Coleus forskohlii supplementation, but it’s important to mention that short-term use has been shown to be safe.

The main bioactive compound in Coleus forskohlii is called forskolin. The standard dose for forskolin is 50 mg, taken in 25 mg doses twice a day. To supplement 25 mg of forskolin, assuming a 10% forskolin Coleus forskohlii extract, take 250 mg of extract. This comes out to 500 mg of the extract total, split up into two daily doses of 250 mg each, taken four to six hours apart.

Your Yohimbe plan

Yohimbine is dosed differently depending on if it is supplemented by itself or as part of a stack. The typical yohimbine dosage is 2.5 – 7.5 mg (250 – 750 mcg), taken twice a day for a total daily dose of 5 – 15 mg. It is strongly recommended to start at the low end of the range before supplementing higher doses.

Rauwolscine is a compound with a similar structure and function as yohimbine. Rauwolscine may provide the same effects as yohimbine and can be used as an alternative, but it has only preliminary evidence for its effects and should be used with caution.

Note: People with anxiety disorders should be especially careful when supplementing yohimbine, as it can exacerbate pre-existing symptoms of anxiety. Yohimbine is recommended for supplementation over the bark of Pausinystalia yohimbe because the isolated compound has fewer side effects than the bark.

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